Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants.

ABSTRACT: Differences in innate immune 'imprinting' between vaccine adjuvants may mediate dissimilar effects on the quantity/quality of persisting adaptive responses. We compared antibody avidity maturation, antibody/memory B cell/CD4⁺ T cell response durability, and recall responses to non-adjuvanted fractional-dose antigen administered 1-year post-immunization (Day [D]360), between hepatitis B vaccines containing Adjuvant System (AS)01_B, AS01_E, AS03, AS04, or Alum (NCT00805389). Both the antibody and B cell levels ranked similarly (AS01_B/E/AS03 > AS04 > Alum) at peak response, at D360, and following their increases post-antigen recall (D390). Proportions of high-avidity antibodies increased post-dose 2 across all groups and persisted at D360, but avidity

SUBMITTER: Budroni S 

PROVIDER: S-EPMC8140094 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature