Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box.

ABSTRACT: Understanding and treating heterogeneous brain disorders requires specialized techniques spanning genetics, proteomics, and neuroimaging. Designed to meet this need, NeuroPM-box is a user-friendly, open-access, multi-tool cross-platform software capable of characterizing multiscale and multifactorial neuropathological mechanisms. Using advanced analytical modeling for molecular, histopathological, brain-imaging and/or clinical evaluations, this framework has multiple applications, validated here with synthetic (N > 2900), in-vivo (N = 911) and post-mortem (N = 736) neurodegenerative data, and including the ability to characterize: (i) the series of sequential states (genetic, histopathological, imaging or clinical alterations) covering decades of disease progression, (ii) concurrent intra-

SUBMITTER: Iturria-Medina Y 

PROVIDER: S-EPMC8140107 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature