Clinical and genetic analysis of melanomas arising in acral sites.

ABSTRACT:

Study aim

Melanomas arising in acral sites are associated with a poorer prognosis than other melanoma subtypes. The aim of this study was to evaluate clinical-pathological and genetic characteristics as well as therapeutic responses of a larger cohort of patients with melanomas arising in acral sites.

Methods

Clinical data of 134 patients with melanomas arising in acral sites from the Dept. of Dermatology Essen were collected and analysed with regard to clinicopathological characteristics and treatment responses. Genetic analysis with targeted next-generation sequencing was done on 50 samples.

Results

In our cohort, BRAF (30%), NRAS (28%), TERT promoter (26%), NF1 (14%) and KIT (6%) were frequently identified mutations. Comparing tumours situated on palms and soles wi

SUBMITTER: Zaremba A 

PROVIDER: S-EPMC8140290 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature