Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

ABSTRACT: Oncolytic viruses are promising cancer therapies due to their selective killing of tumor cells and ability to stimulate the host immune system. As an oncolytic virus platform, vaccinia virus has unique advantages, including rapid replication, a broad range of host targets, and a large capacity for transgene incorporation. In this study, we developed a novel oncolytic vaccinia virus with high potency and a favorable safety profile. We began with the International Health Department-White (IHD-W) strain, which had the strongest cytotoxicity against tumor cells among the four vaccinia virus strains tested. Next, several candidate viruses were constructed by deleting three viral genes (C11R, K3L, and J2R) in various combinations, and their efficacy and safety were compared.

SUBMITTER: Shin J 

PROVIDER: S-EPMC8140350 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature