Fabrication, Rheological, and Compositional Characterization of Thermoresponsive Hydrogel from Cornea.

ABSTRACT: Fabricating thermoresponsive hydrogels from decellularized tissues is a trending and promising approach to develop novel biomaterials for tissue engineering and therapeutic purposes. There are differences in the characteristics of the produced hydrogels related to the source tissue as well as the decellularization and solubilization protocols used. Detailed characterization of the hydrogels will support the efforts to optimize their application as biomaterials for tissue engineering and therapeutics. Here, we describe an optimized method for fabricating an in situ thermoresponsive hydrogel from decellularized porcine cornea extracellular matrix (COMatrix), and provide a detailed characterization of its structure, thermoresponsive rheological behavior (heat-induced sol-gel transition

SUBMITTER: Yazdanpanah G 

PROVIDER: S-EPMC8140359 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature