Alzheimer's disease biomarkers as predictors of trajectories of depression and apathy in cognitively normal individuals, mild cognitive impairment, and Alzheimer's disease dementia.

ABSTRACT:

Objectives

To examine trajectories of depression and apathy over a 5-year follow-up period in (prodromal) Alzheimer's disease (AD), and to relate these trajectories to AD biomarkers.

Methods

The trajectories of depression and apathy (measured with the Neuropsychiatric Inventory or its questionnaire) were separately modeled using growth mixture models for two cohorts (National Alzheimer's Coordinating Center, NACC, n = 22 760 and Alzheimer's Disease Neuroimaging Initiative, ADNI, n = 1 733). The trajectories in ADNI were associated with baseline CSF AD biomarkers (Aβ_42, t-tau, and p-tau) using bias-corrected multinomial logistic regression.

Results

Multiple classes were identified, with the largest classes having no symptoms over time. Lower Aβ₄₂

SUBMITTER: Banning LCP 

PROVIDER: S-EPMC8140398 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature