Genetic diversity analysis of Chinese Leishmania isolates and development of L. donovani complex-specific markers by RAPD.

ABSTRACT:

Background

Leishmaniasis is one of the most neglected tropical diseases in the world and remains endemic in some underdeveloped regions, including western China. The phylogeny and classification of Chinese Leishmania has not been completely clarified to date, especially within the Leishmania (L.) donovani complex, although phylogenetic analyses based on a series of gene markers have been performed. More analytic methods and data are still needed. Random amplified polymorphic DNA (RAPD) technology can sensitively identify slight intraspecific differences, and it is a powerful tool to seek species-specific markers. This work attempted to identify Chinese Leishmania isolates from diverse geographic regions at the genomic level. Meanwhile, specific markers of the L. donovani complex we

SUBMITTER: Yuan D 

PROVIDER: S-EPMC8140445 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature