Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study.

ABSTRACT:

Purpose

The scope of this research endeavor was the determination of the applicability of over the counter mouthwash solutions in reducing the viral load in the saliva of COVID-19 patients and hence decreasing their infectivity. Beyond that, new experimental mouthwashes were investigated in terms of a possible positive immune modulation, which might offer an additional opportunity for a positive pharmaceutical effect.

Methods

The effectivity of the mouth washing solution was determined on 34 hospitalized COVID-19 patients by measuring the viral load by RT-qPCR in pharyngeal swabs, which were taken before and after rinsing. The inflammatory modulation thru the experimental solutions was assayed in an in vitro model of virus infected nasopharyngeal epithelium cells.

Results

SUBMITTER: Schurmann M 

PROVIDER: S-EPMC8140561 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature