SPMLMI: predicting lncRNA-miRNA interactions in humans using a structural perturbation method.

ABSTRACT: Long non-coding RNA (lncRNA)-microRNA (miRNA) interactions are quickly emerging as important mechanisms underlying the functions of non-coding RNAs. Accordingly, predicting lncRNA-miRNA interactions provides an important basis for understanding the mechanisms of action of ncRNAs. However, the accuracy of the established prediction methods is still limited. In this study, we used structural consistency to measure the predictability of interactive links based on a bilayer network by integrating information for known lncRNA-miRNA interactions, an lncRNA similarity network, and an miRNA similarity network. In particular, by using the structural perturbation method, we proposed a framework called SPMLMI to predict potential lncRNA-miRNA interactions based on the bilayer network. We found that t

SUBMITTER: Xu M 

PROVIDER: S-EPMC8140594 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature