Real-time visualization of renal microperfusion using laser speckle contrast imaging.

ABSTRACT: Intraoperative parameters of renal cortical microperfusion (RCM) have been associated with postoperative ischemia/reperfusion injury. Laser speckle contrast imaging (LSCI) could provide valuable information in this regard with the advantage over the current standard of care of being a non-contact and full-field imaging technique. Our study aims to validate the use of LSCI for the visualization of RCM on ex vivo perfused human-sized porcine kidneys in various models of hemodynamic changes. A comparison was made between three renal perfusion measures: LSCI, the total arterial renal blood flow (RBF), and sidestream dark-field (SDF) imaging in different settings of ischemia/reperfusion. LSCI showed a good correlation with RBF for the reperfusion experiment (0.94  ±  0.02; p  <  0.0001) and sho

SUBMITTER: Heeman W 

PROVIDER: S-EPMC8140613 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature