Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk.

ABSTRACT:

Background

A gut-microbial metabolite, trimethylamine N-oxide (TMAO), has been associated with coronary atherosclerotic burden. No previous prospective study has addressed associations of long-term changes in TMAO with coronary heart disease (CHD) incidence.

Objectives

The purpose of this study was to investigate whether 10-year changes in plasma TMAO levels were significantly associated with CHD incidence.

Methods

This prospective nested case-control study included 760 healthy women at baseline. Plasma TMAO levels were measured both at the first (1989 to 1990) and the second (2000 to 2002) blood collections; 10-year changes (Δ) in TMAO were calculated. Incident cases of CHD (n = 380) were identified after the second blood collection through 2016 and were matched to c

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC8140616 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature