RBC Transfusion Induced ST Segment Variability Following the Norwood Procedure.

ABSTRACT: The transfusion of stored RBCs decreases nitric oxide bioavailability, which may have an adverse effect on vascular function. We assessed the effects of RBC transfusion on coronary vascular function by evaluating the relationship between myocardial oxygen delivery and demand as evidenced by ST segment variability.

Design

Retrospective case-control study.

Setting

Nine-hundred seventy-three-bed pediatric hospital with a 54-bed cardiovascular ICU.

Patients

Seventy-three neonates with hypoplastic left heart syndrome following the Norwood procedure, 38 with a Blalock-Taussig shunt and 35 with a right ventricle to pulmonary artery shunt.

Interventions

RBC transfusion.

Materials and main results

High-frequency physiologic data were captured 30 minutes prior to t

SUBMITTER: Savorgnan F 

PROVIDER: S-EPMC8140762 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature