DNA damage response of major fungal pathogen Candida glabrata offers clues to explain its genetic diversity.

ABSTRACT: How cells respond to DNA damage is key to maintaining genome integrity or facilitating genetic change. In fungi, DNA damage responses have been extensively characterized in the model budding yeast Saccharomyces cerevisiae, which is generally not pathogenic. However, it is not clear how closely these responses resemble those in fungal pathogens, in which genetic change plays an important role in the evolutionary arms race between pathogen and host and the evolution of antifungal drug resistance. A close relative of S. cerevisiae, Candida glabrata, is an opportunistic pathogen that displays high variability in chromosome structure among clinical isolates and rapidly evolves antifungal drug resistance. The mechanisms facilitating such genomic flexibility and evolvability in this organism are

SUBMITTER: Shor E 

PROVIDER: S-EPMC8141006 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature