Ontology highlight
ABSTRACT:
SUBMITTER: Thrun A
PROVIDER: S-EPMC8141035 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Thrun Anna A Garzia Aitor A Kigoshi-Tansho Yu Y Patil Pratik R PR Umbaugh Charles S CS Dallinger Teresa T Liu Jia J Kreger Sylvia S Patrizi Annarita A Cox Gregory A GA Tuschl Thomas T Joazeiro Claudio A P CAP
Molecular cell 20210427 10
Incompletely synthesized nascent chains obstructing large ribosomal subunits are targeted for degradation by ribosome-associated quality control (RQC). In bacterial RQC, RqcH marks the nascent chains with C-terminal alanine (Ala) tails that are directly recognized by proteasome-like proteases, whereas in eukaryotes, RqcH orthologs (Rqc2/NEMF [nuclear export mediator factor]) assist the Ltn1/Listerin E3 ligase in nascent chain ubiquitylation. Here, we study RQC-mediated proteolytic targeting of r ...[more]