Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidance.

ABSTRACT:

Background

Although the incidence of positive resection margins in breast-conserving surgery has decreased, both incomplete resection and unnecessary large resections still occur. This is especially the case in the surgical treatment of ductal carcinoma in situ (DCIS). Diffuse reflectance spectroscopy (DRS), an optical technology based on light tissue interactions, can potentially characterize tissue during surgery thereby guiding the surgeon intraoperatively. DRS has shown to be able to discriminate pure healthy breast tissue from pure invasive carcinoma (IC) but limited research has been done on (1) the actual optical characteristics of DCIS and (2) the ability of DRS to characterize measurements that are a mixture of tissue types.

Methods

In this study, DRS spectra were a

SUBMITTER: de Boer LL 

PROVIDER: S-EPMC8141169 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature