Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma.

ABSTRACT:

Background

Replication factor C (RFC) is closely related to tumor progression and metastasis. However, the functional significance of RFC2 in hepatocellular carcinoma remains unclear.

Materials and methods

In order to solve this problem, the expression of RFC2 in liver cancer patients was analyzed through ONCOMINE, UALCAN, Human Protein Atlas. Survival analysis was conducted using Kaplan-Meier plotter and GEPIA. GO and KEGG enrichment analyses were carried out. The protein-protein interaction (PPI) network was performed through Metascape. Western blotting, cell counting kit-8 and transwell assay were used to detect the effect of RFC2 on cell proliferation and migration.

Results

The transcription and protein level of RFC2 in HCC were overexpressed, which was significan

SUBMITTER: Ji Z 

PROVIDER: S-EPMC8141224 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature