Methodological considerations for investigating oral anticoagulation persistence in atrial fibrillation.

ABSTRACT:

Aims

Reports of long-term oral anticoagulant (OAC) therapy for atrial fibrillation (AF) reveal highly variable, and generally suboptimal estimates of medication persistence. The objective of this review is to summarize current literature and highlight important methodological considerations for interpreting persistence research and designing studies of persistence on OAC treatment.

Methods and results

We summarize differences in study methodology, setting, timing, treatment, and other factors associated with reports of better or worse persistence. For example, prospective compared with retrospective study designs are associated with higher reported persistence. Similarly, patient factors such as permanent AF or high stroke risk, and treatment with non-vitamin K oral antagoni

SUBMITTER: Paquette M 

PROVIDER: S-EPMC8141301 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature