LncRNA-Associated Competitive Endogenous RNA Regulatory Network in an Aβ_25-35-Induced AD Mouse Model Treated with Tripterygium Glycoside.

ABSTRACT:

Background

Tripterygium glycoside (TG) has been suggested to have protective effects on the diseases of the central nervous system including Alzheimer's disease (AD). The mechanisms involving lncRNA-associated competing endogenous RNAs (ceRNAs) were shown to play important roles in the development of AD. However, the ceRNA mechanism of TG in treating AD is still unknown. Thus, we aimed to explore the ceRNA mechanism in the treatment of AD with TG.

Methods

A total of 32 C57BL/6J mice were administered 3 µL of Aβ_25-35 (dual side, 1 mg/mL) by a single stereotactic injection in the brain to conduct AD mouse model. AD mouse models were randomly selected and divided into the AD+normal saline (NS) group (n=16) and the AD+TG group (n=16). The expression data of lncRNAs, m

SUBMITTER: Tang L 

PROVIDER: S-EPMC8141406 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature