Non-covalent double bond sensors for gas-phase infrared spectroscopy of unsaturated fatty acids.

ABSTRACT: The position and configuration of carbon-carbon double bonds in unsaturated fatty acids is crucial for their biological functions and influences health and disease. However, double bond isomers are not routinely distinguished by classical mass spectrometry workflows. Instead, they require sophisticated analytical approaches usually based on chemical derivatization and/or instrument modification. In this work, a novel strategy to investigate fatty acid double bond isomers (18:1) without prior chemical treatment or modification of the ion source was implemented by non-covalent adduct formation in the gas phase. Fatty acid adducts with sodium, pyridinium, trimethylammonium, dimethylammonium, and ammonium cations were characterized by a combination of cryogenic gas-phase infrared spectroscopy,

SUBMITTER: Kirschbaum C 

PROVIDER: S-EPMC8141490 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature