Stimulated Immune Response by TruCulture^® Whole Blood Assay in Patients With European Lyme Neuroborreliosis: A Prospective Cohort Study.

ABSTRACT:

Introduction

Borrelia burgdorferi sensu lato complex (B. burgdorferi) can cause a variety of clinical manifestations including Lyme neuroborreliosis. Following the tick-borne transmission, B. burgdorferi initially evade immune responses, later symptomatic infection is associated with occurrence of specific antibody responses. We hypothesized that B. burgdorferi induce immune hyporesponsiveness or immune suppression and aimed to investigate patients with Lyme neuroborreliosis ability to respond to immune stimulation.

Methods

An observational cohort study investigating the stimulated immune response by standardized whole blood assay (TruCulture^®) in adult patients with Lyme neuroborreliosis included at time of diagnosis from 01.09.2018-31

SUBMITTER: Orbæk M 

PROVIDER: S-EPMC8141554 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature