Development and Validation of a CD8+ T Cell Infiltration-Related Signature for Melanoma Patients.

ABSTRACT:

Aim

Immunotherapy shows efficacy in only a subset of melanoma patients. Here, we intended to construct a risk score model to predict melanoma patients' sensitivity to immunotherapy.

Methods

Integration analyses were performed on melanoma patients from high-dimensional public datasets. The CD8+ T cell infiltration related genes (TIRGs) were selected via TIMER and CIBERSORT algorithm. LASSO Cox regression was performed to screen for the crucial TIRGs. Single sample gene set enrichment analysis (ssGSEA) and ESTIMATE algorithm were used to evaluate the immune activity. The prognostic value of the risk score was determined by univariate and multivariate Cox regression analysis.

Results

184 candidate TIRGs were identified in melanoma patients. Based on the candidate

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC8141567 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature