MiRNA Landscape in Pathogenesis and Treatment of Vogt-Koyanagi-Harada Disease.

ABSTRACT: miRNAs, one of the members of the noncoding RNA family, are regulators of gene expression in inflammatory and autoimmune diseases. Changes in miRNA pool expression have been associated with differentiation of CD4⁺ T cells toward an inflammatory phenotype and with loss of self-tolerance in autoimmune diseases. Vogt-Koyanagi-Harada (VKH) disease is a chronic multisystemic pathology, affecting the uvea, inner ear, central nervous system, and skin. Several lines of evidence support an autoimmune etiology for VKH, with loss of tolerance against retinal pigmented epithelium-related self-antigens. This deleterious reaction is characterized by exacerbated inflammation, due to an aberrant T _H 1 and T _H 17 polarization and secretion of their proinflamma

SUBMITTER: Vega-Tapia F 

PROVIDER: S-EPMC8141569 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature