16S rDNA Full-Length Assembly Sequencing Technology Analysis of Intestinal Microbiome in Polycystic Ovary Syndrome.

ABSTRACT:

Objective

To study the characteristics and relationship of the gut microbiota in patients with polycystic ovary syndrome (PCOS).

Method

We recruited 45 patients with PCOS and 37 healthy women from the Reproductive Department of Shengjing Hospital. We recorded their clinical indexes, and sequenced their fecal samples by 16S rDNA full-length assembly sequencing technology (16S-FAST).

Result

We found decreased α diversity and different abundances of a series of microbial species in patients with PCOS compared to healthy controls. We found LH and AMH were significantly increased in PCOS with Prevotella enterotype when compared to control women with Prevotella enterotype, while glucose and lipid metabolism level remained no significant difference, and situati

SUBMITTER: Dong S 

PROVIDER: S-EPMC8141595 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature