The Association Between Clopidogrel and Gastrointestinal Bleeding After Primary Total Joint Arthroplasty.

ABSTRACT:

Background

Anticoagulation after total joint arthroplasty has been demonstrated to reduce venous thromboembolism. However, anticoagulation can lead to adverse bleeding events. The purpose of this study was to assess if an association exists between specific anticoagulation modalities, such as clopidogrel, and postoperative gastrointestinal (GI) bleeding.

Methods

A prospective cohort of Medicare patients undergoing total joint arthroplasty from 2017 to 2019 (3535 patients) was retrospectively reviewed. The baseline characteristics and anticoagulation methods were compared between the "GI bleed" cohort and the "non-GI bleed cohort." Independent t-tests were conducted for continuous variables, while chi-squared analysis was conducted for dichotomous variables.

Results

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SUBMITTER: Kugelman D 

PROVIDER: S-EPMC8141600 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature