Making a Cold Tumor Hot: The Role of Vaccines in the Treatment of Glioblastoma.

ABSTRACT: The use of immunotherapies for the treatment of brain tumors is a topic that has garnered considerable excitement in recent years. Discoveries such as the presence of a glymphatic system and immune surveillance in the central nervous system (CNS) have shattered the theory of immune privilege and opened up the possibility of treating CNS malignancies with immunotherapies. However, despite many immunotherapy clinical trials aimed at treating glioblastoma (GBM), very few have demonstrated a significant survival benefit. Several factors for this have been identified, one of which is that GBMs are immunologically "cold," implying that the cancer does not induce a strong T cell response. It is postulated that this is why clinical trials using an immune checkpoint inhibitor alone have not demonst

SUBMITTER: Frederico SC 

PROVIDER: S-EPMC8141615 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature