Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.

ABSTRACT:

Background

Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients.

Methods

Urine was collected from COVID-19 patients (n = 29) in intensive care and compared to a preoperative group of patients (n = 9) with no critical illness. 92 urinary cytokines were analyzed in multiplex using the Olink Target 96 inflammation panel and compared to clinical characteristics, and urinary markers of kidney injury.

Results

There were strong correlations between proinflammatory cytokines and between urinary cytokines and urinary kidney injury markers in 29 COVID-19 pat

SUBMITTER: Gradin A 

PROVIDER: S-EPMC8141692 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature