Tracing Evolution Through Protein Structures: Nature Captured in a Few Thousand Folds.

ABSTRACT: This article is dedicated to the memory of Cyrus Chothia, who was a leading light in the world of protein structure evolution. His elegant analyses of protein families and their mechanisms of structural and functional evolution provided important evolutionary and biological insights and firmly established the value of structural perspectives. He was a mentor and supervisor to many other leading scientists who continued his quest to characterise structure and function space. He was also a generous and supportive colleague to those applying different approaches. In this article we review some of his accomplishments and the history of protein structure classifications, particularly SCOP and CATH. We also highlight some of the evolutionary insights these two classifications have brought. Final

SUBMITTER: Bordin N 

PROVIDER: S-EPMC8141709 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature