Dataset Information

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.

ABSTRACT: Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs. Numerous interactions of these derivatives at their targets could impact future research considerations and prospects while offering opportunities for optimizing therapeutic activity with fewer adverse effects.

SUBMITTER: Costa RF

PROVIDER: S-EPMC8141747 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.

Costa Rafael Fernades RF Turones Larissa Córdova LC Cavalcante Keilah Valéria Naves KVN Rosa Júnior Ismael Aureliano IA Xavier Carlos Henrique CH Rosseto Lucimar Pinheiro LP Napolitano Hamilton Barbosa HB Castro Patrícia Ferreira da Silva PFDS Neto Marcos Luiz Ferreira MLF Galvão Gustavo Mota GM Menegatti Ricardo R Pedrino Gustavo Rodrigues GR Costa Elson Alves EA Martins José Luis Rodrigues JLR Fajemiroye James Oluwagbamigbe JO

Frontiers in pharmacology 20210510

Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyr ...[more]

PMID: 34040529

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Dataset Information

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.

Publications

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.

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