Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties.

ABSTRACT: There is no targeted effective treatment for patients undergoing internal fixation surgery/two-stage total joint revision surgery with a high risk of postoperative infection and osteolysis, while the rate of reoperation due to infection and osteolysis remains high. In this study, we report a pioneering application of implants made of biodegradable Zn-Ag alloy with active antibacterial and anti-osteolytic properties in three classical animal models, illustrating antibacterial, anti-osteolysis, and internal fixation for fractures. The antibacterial activity of the Zn-2Ag alloy was verified in a rat femur osteomyelitis prevention model, while the anti-osteolytic properties were evaluated using a mouse cranial osteolysis model. Moreover, the Zn-2Ag based screws showed similar performance in bo

SUBMITTER: Qu X 

PROVIDER: S-EPMC8141820 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature