Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds.

ABSTRACT: Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex challenge. Therefore, we present a novel hemostatic strategy based on magnetic field-mediated guidance. The biphasic Janus magnetic particle (MSS@Fe₂O₃-T) comprised aggregates of α-Fe₂O₃ nanoparticles (Fe₂O₃ NPs) as the motion actuator, negatively modified microporous starch (MSS) as the base hemostatic substrate, and thrombin as the loaded hemostatic drug. Before application, the particles were first wrapped using NaHCO₃ and then doped with protonated tranexamic acid (TXA-NH₃ ⁺), which ensured their high self-dispersibility in li

SUBMITTER: Li Q 

PROVIDER: S-EPMC8141897 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature