Comparative Analysis of the Circular Transcriptome in Muscle, Liver, and Testis in Three Livestock Species.

ABSTRACT: Circular RNAs have been observed in a large number of species and tissues and are now recognized as a clear component of the transcriptome. Our study takes advantage of functional datasets produced within the FAANG consortium to investigate the pervasiveness of circular RNA transcription in farm animals. We describe here the circular transcriptional landscape in pig, sheep and bovine testicular, muscular and liver tissues using total 66 RNA-seq datasets. After an exhaustive detection of circular RNAs, we propose an annotation of exonic, intronic and sub-exonic circRNAs and comparative analyses of circRNA content to evaluate the variability between individuals, tissues and species. Despite technical bias due to the various origins of the datasets, we were able to characterize some features

SUBMITTER: Robic A 

PROVIDER: S-EPMC8141914 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature