Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection.

ABSTRACT: Gut microbiota educate the local and distal immune system in early life to imprint long-term immunological outcomes while maintaining the capacity to dynamically modulate the local mucosal immune system throughout life. It is unknown whether gut microbiota provide signals that dynamically regulate distal immune responses following an extra-gastrointestinal infection. We show here that gut bacteria composition correlated with the severity of malaria in children. Using the murine model of malaria, we demonstrate that parasite burden and spleen germinal center reactions are malleable to dynamic cues provided by gut bacteria. Whereas antibiotic-induced changes in gut bacteria have been associated with immunopathology or impairment of immunity, the data demonstrate that antibiotic-induced chang

SUBMITTER: Mandal RK 

PROVIDER: S-EPMC8141963 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature