Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.

ABSTRACT:

Background

Height and other anthropometric measures are consistently found to associate with differential cancer risk. However, both genetic and mechanistic insights into these epidemiological associations are notably lacking. Conversely, inherited genetic variants in tumour suppressors and oncogenes increase cancer risk, but little is known about their influence on anthropometric traits.

Methods

By integrating inherited and somatic cancer genetic data from the Genome-Wide Association Study Catalog, expression Quantitative Trait Loci databases and the Cancer Gene Census, we identify SNPs that associate with different cancer types and differential gene expression in at least one tissue type, and explore the potential pleiotropic associations of these SNPs with anthropometric

SUBMITTER: Di Giovannantonio M 

PROVIDER: S-EPMC8142426 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature