Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism.

ABSTRACT:

Objective

To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism.

Methods

Hypervariable V3-V4 regions of the bacterial 16S rRNA gene from fecal samples of gout patients with and without tophi (n = 33 and n = 25, respectively) were sequenced and compared to fecal samples from 53 healthy controls. We explored predictive functional profiles using bioinformatics in order to identify differences in taxonomy and metabolic pathways.

Results

We identified a microbiome characterized by the lowest richness and a higher abundance of Phascolarctobacterium, Bacteroides, Akkermansia, and Ruminococcus_gnavus_group genera in patients with gout without

SUBMITTER: Mendez-Salazar EO 

PROVIDER: S-EPMC8142508 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature