Methanol extract of Iphiona aucheri ameliorates CCl₄ induced hepatic injuries by regulation of genes in rats.

ABSTRACT: We have investigated the protective potential of methanol extract of Iphiona aucheri (IAM) on the expression of endoplasmic reticulum (ER) stress associated genes and inflammatory genes on carbon tetrachloride (CCl₄) induced hepatic toxicity in rats. Hepatic damage markers: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin were elevated while the content of antioxidants: catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and reduced glutathione (GSH) were decreased significantly (p < 0.05) in CCl₄ treated rats as compared to the control group. The CCl₄ intoxication induced a higher expression of glucose-regulated protein 78 kDa (GRP78), X-box-binding protein 1 total (XBP1t), sp

SUBMITTER: Zai JA 

PROVIDER: S-EPMC8142630 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature