Effect of plasma vitamin C levels on Parkinson's disease and age at onset: a Mendelian randomization study.

ABSTRACT:

Background

Until now, epidemiological evidence regarding the association between vitamin C intake (both diet and supplements) and Parkinson's disease (PD) remains inconsistent. Hence, it is necessary to establish the causal link between vitamin C levels and PD, and further develop effective therapies or prevention.

Methods

We selected 11 newly identified plasma vitamin C genetic variants from a large-scale plasma vitamin C GWAS dataset (n = 52,018) as the effective instrumental variables, and extracted their corresponding GWAS summary statistics from PD (33,674 PD cases and 449,056 controls) and PD age at onset (AAO) (n = 28,568). We then performed a Mendelian randomization (MR) study to evaluate the causal association of plasma vitamin C levels with PD and PD AAO using inve

SUBMITTER: Liu H 

PROVIDER: S-EPMC8142636 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature