Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia.

ABSTRACT:

Background

Cerebrovascular disorders have occurred more frequently in some Central Nervous System (CNS) disorders, such as epilepsy. Some CNS drugs have been associated with increased stroke risk. Our aim was to estimate the risk of ischaemic stroke in patients exposed to antiepileptic drugs (AED).

Methods

Population-based matched case-control study using SIDIAP database, based in electronic health records from primary healthcare from Catalonia, Spain. Cases were those patients with a registered diagnosis of first stroke during 2009-2014. Up to 10 controls were selected for each case and matched by sex, age, and geographic area and without a prior diagnosis of stroke. We considered global drug exposure to AED, past and current exposure and exposure in monotherapy to each AED

SUBMITTER: Giner-Soriano M 

PROVIDER: S-EPMC8142644 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature