Ontology highlight
ABSTRACT:
SUBMITTER: Kamel W
PROVIDER: S-EPMC8142890 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kamel Wael W Noerenberg Marko M Cerikan Berati B Chen Honglin H Järvelin Aino I AI Kammoun Mohamed M Lee Jeffrey Y JY Shuai Ni N Garcia-Moreno Manuel M Andrejeva Anna A Deery Michael J MJ Johnson Natasha N Neufeldt Christopher J CJ Cortese Mirko M Knight Michael L ML Lilley Kathryn S KS Martinez Javier J Davis Ilan I Bartenschlager Ralf R Mohammed Shabaz S Castello Alfredo A
Molecular cell 20210524 13
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a multi-omic approach to identify systematically and comprehensively the cellular and viral RBPs that are involved in SARS-CoV-2 infection. We reveal that SARS-CoV-2 infection profoundly remodels the cellular RNA-bound proteome, ...[more]