The landscape of tumors-infiltrate immune cells in papillary thyroid carcinoma and its prognostic value.

ABSTRACT:

Introduction

Thyroid cancer is a very common malignant tumor in the endocrine system, while the incidence of papillary thyroid carcinoma (PTC) throughout the world also shows a trend of increase year by year. In this study, we constructed two models: ICIscore and Riskscore. Combined with these two models, we can make more accurate and reasonable inferences about the prognosis of PTC patients.

Methods

We selected 481 PTC samples from TCGA and 147 PTC samples from GEO (49 samples in GSE33630, 65 samples in GSE35570 and 33 samples in GSE60542). We performed consistent clustering for them and divided them into three subgroups and screened differentially expressed genes from these three subgroups. Then we divided the differential genes into three subtypes. We also distinguished t

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8142931 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature