Survival After Implantable Cardioverter-Defibrillator Shocks.

ABSTRACT:

Background

There are conflicting data on the impact of implantable cardioverter-defibrillator (ICD) shocks on subsequent mortality.

Objectives

The aim of this study was to determine whether the arrhythmic substrate leading to ICD therapy or the therapy itself increases mortality.

Methods

The study cohort included 5,516 ICD recipients who were enrolled in 5 landmark ICD trials (MADIT-II, MADIT-RISK, MADIT-CRT, MADIT-RIT, RAID). The authors evaluated the association of device therapy with subsequent mortality in 4 separate time-dependent models: model I, type of ICD therapy; model II, type of arrhythmia for which ICD therapy was delivered; model III, combined assessment of all arrhythmia and therapy types during follow-up; and model IV, incremental risk associated with

SUBMITTER: Aktas MK 

PROVIDER: S-EPMC8142936 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature