Androgen deprivation therapy in men with node-positive prostate cancer treated with postoperative radiotherapy.

ABSTRACT:

Background

In men with node-positive prostate cancer after radical prostatectomy there are limited data on the value of adding androgen deprivation therapy (ADT) to postoperative radiotherapy.

Objective

To determine whether there is a clear oncologic benefit to ADT in the setting of node-positive prostate cancer treated with postoperative radiotherapy.

Methods

We analyzed data for 372 prostate cancer patients treated at San Raffaele Hospital with postoperative radiotherapy for node-positive disease after radical prostatectomy, 272 received both ADT and radiotherapy. Eighty-six men were followed without an event for more than 10 years.

Results

Patients who received postoperative radiotherapy + ADT had more aggressive disease, with higher preoperative PSA level,

SUBMITTER: Bravi CA 

PROVIDER: S-EPMC8142939 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature