Increased Incidence of Venous Thromboembolism with Cancer Immunotherapy.

ABSTRACT:

Background

Cancer immunotherapy is associated with several immune-related adverse events, but the relationship between immunotherapy and venous thromboembolism has not been thoroughly studied.

Methods

We conducted a retrospective cohort study of 1,686 patients who received immunotherapy for a variety of malignancies to determine the incidence of venous thromboembolism and the impact of venous thromboembolism on survival. To examine the potential role of inflammation in venous thromboembolism, we also profiled immune cells and plasma cytokines in blood samples obtained prior to initiation of immunotherapy in a sub-cohort of patients treated on clinical trials who subsequently did (N = 15), or did not (N = 10) develop venous thromboembolism.

Findings

Venous thromboembol

SUBMITTER: Roopkumar J 

PROVIDER: S-EPMC8143033 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature