Screening and Selection of a New Medium for Diosgenin Production via Microbial Biocatalysis of Fusarium sp.

ABSTRACT: Steroidal saponins are widely used as starting precursors and medical intermediates for the semi-/total-synthesis of hundreds of steroidal drugs. One such steroidal saponin is diosgenin, which has attracted significant attention due to the huge market demand in the pharmaceutical industry. Due to water waste and severe environmental pollution, the traditional diosgenin production process based on direct acid hydrolysis is no longer used. In this study, to develop a submerged fermentation (SmF) medium for clean diosgenin production via efficient microbial biocatalysis, the Box-Behnken design (BBD) in combination with the Plackett-Burman design (PBD) was used to determine the medium compositions for Fusarium strains. Three components (wheat bran, phosphate, and Tween-80) were determined as s

SUBMITTER: Liu W 

PROVIDER: S-EPMC8143133 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature