Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.

ABSTRACT: Tau aggregation within neurons is a critical feature of Alzheimer's disease (AD) and related tauopathies. It is believed that soluble pathologic tau species seed the formation of tau aggregates in a prion-like manner and propagate through connected neurons during the progression of disease. Both soluble and aggregated forms of tau are thought to have neurotoxic properties. In addition, different strains of misfolded tau may cause differential neurotoxicity. In this work, we present an accelerated human neuronal model of tau-induced neurotoxicity that incorporates both soluble tau species and tau aggregation. Using patient-derived induced pluripotent stem cell (iPSC) neurons expressing a tau aggregation biosensor, we develop a cell culture system that allows continuous assessment of both in

SUBMITTER: Oakley DH 

PROVIDER: S-EPMC8143197 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature