Sex-specific associations with DNA methylation in lung tissue demonstrate smoking interactions.

ABSTRACT: Cigarette smoking impacts DNA methylation, but the investigation of sex-specific features of lung tissue DNA methylation in smokers has been limited. Women appear more susceptible to cigarette smoke, and often develop more severe lung disease at an earlier age with less smoke exposure. We aimed to analyse whether there are sex differences in DNA methylation in lung tissue and whether these DNA methylation marks interact with smoking. We collected lung tissue samples from former smokers who underwent lung tissue resection. One hundred thirty samples from white subjects were included for this analysis. Regression models for sex as a predictor of methylation were adjusted for age, presence of COPD, smoking variables and technical batch variables revealed 710 associated sites. 294 sites demons

SUBMITTER: Koo HK 

PROVIDER: S-EPMC8143227 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature