Age-related DNA methylation in paired normal and tumour breast tissue in Chinese breast cancer patients.

ABSTRACT: Age-related DNA methylation is a potential mechanism contributing to breast cancer development. Studies of primarily Caucasian women have identified many CpG sites of age-related methylation in non-diseased breast tissue possibly driving cancer development over time. There is a paucity of studies involving Asian women whose ages at breast cancer onset are usually younger than Caucasians. We identified the 181 most consistent age-related methylation events in non-diseased breast tissue across published studies. Age-related methylation events were measured in adjacent normal and breast tumour tissue in an exclusively Asian population at the previously identified age-related methylation sites. Age-related methylation was found in 118 probes in adjacent normal breast tissue. Methylation of 99%

SUBMITTER: Kiely M 

PROVIDER: S-EPMC8143246 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature