Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.

ABSTRACT: To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells tend to rewire their metabolic pathways. Although different types of malignant cells share this phenomenon, there is a large intracellular variability how these metabolic patterns are altered. Fortunately, differences in metabolic patterns between normal tissue and malignant cells can be exploited to increase the therapeutic ratio. Modulation of cellular metabolism to improve treatment outcome is an emerging field proposing a variety of promising strategies in primary tumor and metastatic lesion treatment. These strategies, capable of either sensitizing or protecting tissues, target either tumor or normal tissue and are often focused on modulating of tissue oxygenation, hypoxia-inducible factor (HIF

SUBMITTER: van Gisbergen MW 

PROVIDER: S-EPMC8143268 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature