Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression.

ABSTRACT: Many studies evaluated the functional role of adult hippocampal neurogenesis (AHN) and its key role in cognitive functions and mood regulation. The effects of promoting AHN on the recovery of stress-induced symptoms have been well studied, but its involvement in stress resilience remains elusive. We used a mouse model enabling us to foster AHN before the exposure to unpredictable chronic mild stress (UCMS) to evaluate the potential protective effects of AHN on stress, assessing the depressive-like phenotype and executive functions. For this purpose, an inducible transgenic mouse model was used to delete the pro-apoptotic gene Bax from neural progenitors four weeks before UCMS, whereby increasing the survival of adult-generated neurons. Our results showed that UCMS elicited a depress

SUBMITTER: Planchez B 

PROVIDER: S-EPMC8143348 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature