A Novel Fluorescent Probe for Selective Detection of Hydrazine and Its Application in Imaging.

ABSTRACT: In this work, a novel fluorescent probe with first-time-selected thiazepine backbone, TZPzine-1, was developed for selective detection of hydrazine in water samples and living cells. Chosen from our recent anti-cancer agents, TZPzine-1 inferred structurally based advantages of the optical adjustability and the hydrazine-trapping approach. It also showed applicable properties including high sensitivity (LOD = 50 nM), wide linear range (0-15 equiv.), high selectivity (especially from competing species), rapid response (within 20 min), and practical steadiness in various pH (6.0-11.0) and temperature (15-50 °C) conditions. To satisfy the interdisciplinary requirements in environmental toxicology, TZPzine-1 was successfully applied in water samples and living cells. We hope that the informatio

SUBMITTER: Man RJ 

PROVIDER: S-EPMC8143562 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature