Hepatitis B core-related antigen reflects viral replication and protein production in chronic hepatitis B patients.

ABSTRACT:

Background

Hepatitis B core-related antigen (HBcrAg) is a promising disease-monitoring marker for chronic hepatitis B (CHB). We investigated correlations between HBcrAg with antiviral efficacy and virological and histological variables.

Methods

One hundred and forty-five CHB patients from the mainland of China between August 2013 and September 2016 who underwent liver biopsy received entecavir therapy and had paired liver biopsy at 78 weeks. We analyzed correlations between HBcrAg and virological and histological variables in hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients. We also explored the predictors of HBeAg loss after 78 weeks of antiviral therapy. Pearson correlation analysis and logistic forward stepwise regression were the main statistic methods.

SUBMITTER: Li J 

PROVIDER: S-EPMC8143780 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature